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Theoretical and Practical Consideration for Establishing Sensitivity of Measurements (Updated!)

Understanding and Implementing LOD and LOQ and their relationship to MDL and PQL


This 3-hour interactive webcast reviews materials and techniques that laboratories, data users and assessors can use to successfully address the challenges of complying with the 2016 TNI Standard, and the 2017 EPA Method Detection Limit (MDL) procedure while implementing effective and scientifically sound practices for measuring sensitivity in environmental analysis. A strong focus will be on understanding the theory, interrelationships and practical considerations associated with Limit of Detection (LOD), Limit of Quantitation (LOQ), MDL and concepts established by Lloyd Curie.

Establishing and maintaining a practical approach for the TNI requirements for LOD/LOQ is one of the most confusing and complicated challenges for laboratory management. A good deal of the confusion centers on "what is needed"," why is it needed" , "how does a small laboratory manage the paperwork" and" how do I reconcile this with the requirements of EPA's method detection limit and the alphabet soup of differing reporting requirements". This workshop explores the origins of method detection and quantitation, the theory behind these concepts and most importantly how to apply these concepts to establishing laboratory practices that are meaningful, scientifically based and compliant with the TNI accreditation requirements.

The presenter will focus on practical definition and use of these concepts, review of current EPA requirements, the 2016 TNI standard, actual real-life options and considerations and suggested processes for evaluating sensitivity and reporting systems. Questions are encouraged and welcome. Several options for participants to provide feedback, including their own experiences, solutions and frustrations will be provided.


Laboratory Assessors, Data Users, Quality Managers, Laboratory Managers

Learning Outcomes:

  • Gain awareness of the theory and background used in developing the requirements for detection and quantitation in the 2016 TNI Standard.
  • Be able to discuss the pros and cons of using the old and new EPA Method Detection Limit (MDL) procedures to report data, as well as when it is required.
  • Gain awareness as to the various alternative procedures for establishing claimed Limit of Detection (LOD) and Limit of Quantitation (LOQ).
  • Understand the basic procedure for calculating an MDL.
  • Understand the basic requirements of the TNI Standard for LOD and LOQ.
  • Be able to discuss the importance and benefits of analytically verifying the LOD and LOQ to generate data of known and documented quality.
  • Be able to implement the requirements for LOD and LOQ in your laboratory or for assessing laboratories.

$75 for TNI members and $90 for non-members
$325 group rate (5+ students) for TNI members, $400 group rate (5+ students) for non-members

Note: No certificates are automatically provided with this training. If you wish to receive a Certificate of Completion (CoC) for your records, there will be an additional $30 charge per person for the course. A passing score of at least 70% must be received on the exam in order to receive CEUs and a CoC. Scores of less than 70% will receive a Certificate of Attendance. When you have completed the course, contact Suzanne Rachmaninoff at for your certificate.



Start Date:
Friday 30th October 2020, 12:00pm EDT

3 hours

Presented By:

Jerry Parr

About the Presenter:
Jerry Parr is the Principal Scientist with Catalyst Information Resources, a company focused on providing current relevant information on environmental laboratory issues. He also serves as the Executive Director for The NELAC Institute, serves on the Advisory Board for the Environmental Laboratory Washington Report, and is the conference organizer for the National Environmental Monitoring Conference. He has a BS in Chemistry from the University of Texas at Austin and has 40 years of experience in environmental analytical chemistry.