SIR #: 229
Standard: 2009 TNI
Section: V1M4, Section 126.96.36.199.3
2009 Standard states in 188.8.131.52.3...
Note: The matrix spike may be used in place of this control as long as the acceptance criteria are as stringent as for the LCS.
Is it the intent of the standard that when evaluated by the same criteria, a passing MS replace the LCS in its totality or can an individual target compound failure in the LCS be replaced by an individual acceptable result in a matrix spike sample?
TNI FINAL RESPONSE:
The standards states as a note in 184.108.40.206.3 that "The matrix spike may be used in place of this control as long as the acceptance criteria are as stringent as for the LCS."
This statement in the standards does not allow a matrix spike to be used in place of a failing LCS either in its totality or for an individual target compound. A matrix spike may however be used in place of an LCS if an LCS is not analyzed as required and the LCS control limits are used to evaluate the MS. If a method has specific requirements for an LCS this note does not supersede those method requirements.